NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2 . Can also catalyze to a smaller extent, the reduction of oxygen to superoxide . May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity . May regulate insulin signaling cascade . May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB . May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation . ; [Isoform 4]: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor . Involved in redox signaling in vascular cells . Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage . ; [Isoform 3]: Lacks superoxide-generating NADPH oxidase activity.

NADPH oxidase 4 (EC 1.6.3.1) (Kidney oxidase-1) (KOX-1) (Kidney superoxide-producing NADPH oxidase) (Renal NAD(P)H-oxidase)

q9nph5

Human,Rat

WB,IHC,IF,ICC,FC

WB 1:1000-1:5000
IHC 1:100-1:500
IF 1:200-1:500
ICC 1:200-1:500
FC 1:100-1:200

~67 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.