Heat-shock transcription factor that specifically binds heat shock promoter elements . Required for denucleation and organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light . In this process, may regulate denucleation of lens fiber cells in part by activating DNASE2B transcription . May be involved in DNA repair through the transcriptional regulation of RAD51 . May up-regulate p53/TP53 protein in eye lens fiber cells, possibly through protein stabilization . In the eye lens, controls the expression of alpha-crystallin B chain/CRYAB and consequently may be involved in the regulation of lysosomal acidification . ; [Isoform HSF4A]: Transcriptional repressor. ; [Isoform HSF4B]: Transcriptional activator.

Heat shock factor protein 4 (HSF 4) (hHSF4) (Heat shock transcription factor 4) (HSTF 4)

q9ulv5

Human

WB,IHC,IF,ICC,FC

WB 1:2000-1:10000
IHC 1:50-1:100
IF 1:50-1:100
ICC 1:50-1:100
FC 1:20-1:50

~54 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.