A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion . Required for adherens and desmosome junction assembly in response to mechanical force in keratinocytes . Required for desmosome-mediated cell-cell adhesion of cells surrounding the telogen hair club and the basal layer of the outer root sheath epithelium, consequently is essential for the anchoring of telogen hairs in the hair follicle . Required for the maintenance of the epithelial barrier via promoting desmosome-mediated intercellular attachment of suprabasal epithelium to basal cells . May play a role in the protein stability of the desmosome plaque components DSP, JUP, PKP1, PKP2 and PKP3 . Required for YAP1 localization at the plasma membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, PKP1 and YWHAG . May also be involved in the positive regulation of YAP1 target gene transcription and as a result cell proliferation . Positively regulates cellular contractility and cell junction formation via organization of cortical F-actin bundles and anchoring of actin to tight junctions, in conjunction with RAC1 . The cytoplasmic pool of DSG3 is required for the localization of CDH1 and CTNNB1 at developing adherens junctions, potentially via modulation of SRC activity . Inhibits keratinocyte migration via suppression of p38MAPK signaling, may therefore play a role in moderating wound healing .

Desmoglein-3 (130 kDa pemphigus vulgaris antigen) (PVA) (Cadherin family member 6)

p32926

Human

IHC

IHC 1:100-1:200

~108 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.