A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins . Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma . ; [Isoform 2]: Tyrosine phosphatase that acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling . In addition to its tyrosine phosphatase activity has ecto-5'-nucleotidase activity in dorsal root ganglion neurons. Generates adenosine from AMP which acts as a pain suppressor . ; [PAPf39]: Forms amyloid beta-sheet fibrils in semen. These fibrils, termed SEVI capture HIV virions, attach them to target cells and enhance infection . SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate , a constituent of green tea . Target cell attachment and enhancement of HIV infection is inhibited by surfen . Also similarly boosts XMRV infection .

Prostatic acid phosphatase (PAP) (EC 3.1.3.2) (5'-nucleotidase) (5'-NT) (EC 3.1.3.5) (Acid phosphatase 3) (Ecto-5'-nucleotidase) (Protein tyrosine phosphatase ACP3) (EC 3.1.3.48) (Thiamine monophosphatase) (TMPase) [Cleaved into: PAPf39]

p15309

Human

WB,IHC,IP

WB 1:1000-1:5000
IHC 1:200-1:500
IP 1:10-1:100

~45 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.