Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma . Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy . Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation . However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production . Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis , an integral part of host defense against pathogens, in response to bacterial infection . It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation . Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization .

Pyrin

q9jj26

Mouse

WB,IP

WB 1:1000
IP 1:100

~87 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.