Serum and glucocorticoid-inducible kinase (SGK) is a serine/threonine kinase closely related to Akt. SGK is rapidly induced in response to a variety of stimuli, including serum, glucocorticoid, follicle stimulating hormone, osmotic shock, and mineralocorticoids. SGK activation can be accomplished via HGF PI3K-dependent pathways and by integrin-mediated PI3K-independent pathways. Induction and activation of SGK has been implicated in activating the modulation of anti-apoptotic and cell cycle regulation. SGK also plays an important role in activating certain potassium, sodium, and chloride channels, suggesting its involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. SGK is negatively regulated by ubiquitination and proteasome degradation.

Serine/threonine-protein kinase Sgk1; Serum/glucocorticoid-regulated kinase 1; SGK1; SGK; Serine/threonine-protein kinase Sgk2Serum/glucocorticoid-regulated kinase 2; SGK2; Serine/threonine-protein kinase Sgk3; Cytokine-independent survival kinase; Serum/glucocorticoid-regulated kinase 3; Serum/glucocorticoid-regulated kinase-like; SGK3; CISK; SGKL

o00141/q9hby8/q96br1

Human,Rat,Mouse

WB

WB 1:2000-1:5000

~ 58 kDa

Rabbit

This antibody detects endogenous levels of SGK protein.

Synthetic peptide, corresponding to Human SGK.

Polyclonal

Rabbit IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1mg/ml

Store at 4℃ short term,and store at -20℃ long term. Avoid freeze-thaw cycles.