Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E).

G protein beta subunit like;
G protein beta subunit-like;
Gable;
GBL;
GBL protein;
LST8;
Mammalian lethal with SEC13 protein 8;
MGC111011;
mLST8;
Protein GbetaL;
Target of rapamycin complex subunit LST8;
TORC subunit LST8;

q9bvc4

Human,Mouse,Rat

WB

WB 1:500-1:1000

~ 36 kDa

Rabbit

This antibody detects endogenous levels of MLST8 protein.

Synthetic peptide, corresponding Human MLST8.

Polyclonal

Rabbit IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1mg/ml

Store at 4℃ short term,and store at -20℃ long term. Avoid freeze-thaw cycles.