Substance P (also designated NK-1) is an active peptide, known as a Tachykinin, that affects diverse functions, including blood pressure regulation, peristalsis of the gut, salivation and the modulation of cellular immunity. Frag-ments of Substance P have differential binding capacities for Substance P receptors and have varying biological activities. For example, two amino- terminal fragments of Substance P are able to evoke an increase in GABA release. NK-1 receptor (NK-1R), also designated Substance P receptor, binds to Tachykinin peptides, including Substance P, Substance K and Neuromedin K. In response to Substance P binding, NK-1R signals IL-12 production.

Protachykinin-1; PPT; TAC1; SP

p20366

Human,Mouse,Rat

IHC,IF,ICC

IHC 1:100-1:500
IF 1:100-1:500
ICC 1:100-1:400

~ 15 kDa

Rabbit

This antibody reacts specifically with Substance P. No crossreactivity with related tachykinins (Neurokinin A, Neurokinin B, and Kassinin).

Synthetic peptide, corresponding to mature of Substance P of human origin.

Polyclonal

Rabbit IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1mg/ml

Store at 4℃ short term,and store at -20℃ long term. Avoid freeze-thaw cycles.