p68 RNA Helicase is a nuclear protein that exhibits RNA-dependent ATPase activity. Phosphorylation by protein kinase C inhibits p68 RNA Helicase activity. p68 RNA Helicase appears to play a role in organ differentiation during development. Furthermore, p68 RNA Helicase is expressed in early neural development and in various mesodermal tissues in a number of different chordate embryos. At the cellular level, the expression levels of p68 RNA Helicase increase in serum-induced quiescent cell lines. p68 RNA Helicase may function as a coactivator for estrogen receptor α. Additionally, p68 RNA Helicase associates with transcriptional coactivators CBP and p300. p68 RNA Helicase localizes to the nucleus under normal conditions. During late telophase, p68 RNA Helicase and fibrillarin co-localize to nascent nucleoli. p68 RNA Helicase may function as a heterodimer with p72 RNA Helicase.

ATP dependent RNA helicase DDX5;
DDX 5;
Ddx5;
DDX5;
DEAD (Asp Glu Ala Asp) box helicase 5;
DEAD (Asp Glu Ala Asp) box polypeptide 5;
DEAD box 5;
DEAD box protein 5;
DEAD/H (Asp Glu Ala Asp/His) box polypeptide 5 (RNA helicase; 68kD);
DEAD/H (Asp Glu Ala Asp/His) box polypeptide 5;
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase 68kDa);
DEAD/H box-5 (RNA helicase 68kD);
DKFZp686J01190; G17P1;
HELR;
HLR 1;
HLR1;
HUMP68;
P68;
P68;
p68 RNA he

p17844

Human,Mouse,Rat

WB

WB 1:500-1:1000

~ 68 kDa

Rabbit

This antibody detects endogenous levels of p68 RNA Helicase protein.

Synthetic peptide, corresponding to amino acids 550-600 of Human p68 RNA Helicase.

Polyclonal

Rabbit IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1mg/ml

Store at 4℃ short term,and store at -20℃ long term. Avoid freeze-thaw cycles.