The Hox proteins play a role in development and cellular differentiation by regulating downstream target genes. Specifically, the Hox proteins direct DNA-protein and protein-protein interactions that assist in determining the morphologic features associated with the anterior-posterior body axis. Themammalian Hox gene complex consists of 39 genes that are located on four linkage groups, which are dispersed over four chromosomes. Hox genes that occupy the same relative position along the 5'' to 3'' coordinate (trans-paralogous genes) are more similar in sequence and expression pattern than adjacent Hox genes on the same chromosome. In mice, the HoxB cluster contains HoxB1 to HoxB9 and HoxB13, which are transcribed in the same direction. HoxB9 associates with the transcriptional cofactors BTG1 and BTG2, which enhance HoxB9 ranscription. Alterations in HoxB9 expression, as with other Hox family member, has been implicated in leukemia.

Homeobox protein Hox-B9; Homeobox protein Hox-2.5; Homeobox protein Hox-2E; HOXB9; HOX2E

p17482

Human,Mouse,Rat

WB,IHC

WB 1:500-1:1000
IHC 1:50-1:200

~ 28 kDa

Rabbit

This antibody detects endogenous levels of Hox-B9 protein.

Synthetic peptide, corresponding to amino acids 200-250 of Human Hox-B9.

Polyclonal

Rabbit IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1mg/ml

Store at 4℃ short term,and store at -20℃ long term. Avoid freeze-thaw cycles.