Seven complementation groups (A-G) of xeroderma pigmentosum have been described. The xeroderma pigmentosum group A protein, XPA, is a zinc metalloprotein which preferentially binds to DNA damaged by ultraviolet (UV) radiation and chemical carcinogens. XPA is a DNA repair enzyme that has been shown to be required for the incision step of nucleotide excision repair. XPG (also designated ERCC5) is an endonuclease that makes the 3’ incision in DNA nucleotide excision repair. Mammalian XPG is similar in sequence to yeast RAD2. Conserved residues in the catalytic center of XPG are important for nuclease activity and function in nucleotide excision repair.

COFS 3; COFS3; DNA excision repair protein ERCC 5; DNA excision repair protein ERCC-5; ERCC 5; ERCC5; ERCC5; ERCM 2; ERCM2; Excision Repair Cross Complementing Rodent Repair Deficiency; XPG; XPG complementing protein; XPGC;

p28715

Human

WB,IHC

WB 1:500-1:1000
IHC 1:50-1:200

~ 133, 200 kDa

Rabbit

This antibody detects endogenous levels of XPG protein.

Synthetic peptide, corresponding to amino acids 130-180 of Human ERCC5/XPG.

Polyclonal

Rabbit IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1mg/ml

Store at 4℃ short term,and store at -20℃ long term. Avoid freeze-thaw cycles.