Mitochondrial ribosomes consist of a large 39S subunit and a small 28S subunit, both of which are comprised of multiple mitochondrial ribosomal proteins (MRPs) that are encoded by nuclear genes and are essential for protein synthesis within mitochondria. MRP-L18 (mitochondrial ribosomal protein L18), also known as L18mt or HSPC071, is a 180 amino acid protein that localizes to the mitochondrion, where it exists as a component of the 39S ribosomal subunit and works in conjunction with MRPs to mediate protein synthesis. The gene encoding MRP-L18 maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson''s disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.

39S ribosomal protein L18, mitochondrial; L18mt; MRP-L18

q9h0u6

Human

WB

WB 1:500-1:1000

~ 20 kDa

Rabbit

This antibody detects endogenous levels of MRPL18 protein.

Synthetic peptide, corresponding to amino acids 7-51 of Human MRPL18.

Polyclonal

Rabbit IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1mg/ml

Store at 4℃ short term,and store at -20℃ long term. Avoid freeze-thaw cycles.