RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease (By similarity).

piRNA biogenesis protein EXD1 (Exonuclease 3''-5'' domain-containing protein 1) (Exonuclease 3''-5'' domain-like-containing protein 1) (Inactive exonuclease EXD1)
EXD1 EXDL1 EXDL1

Q8NHP7

Human

WB,IF,ICC,FC

WB 1:500
IF 1:100
ICC 1:100-1:400
FC 1:100

58.2 kDa

Mouse

Full length human recombinant protein of human EXD1 (NP_689809) produced in HEK293T cell.

Monoclonal

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Store at -20 °C. Stable for 12 months from date of receipt.