Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840).; (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1.; (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.

Junctional adhesion molecule A (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet F11 receptor) (Platelet adhesion molecule 1) (PAM-1) (CD antigen CD321)
F11R JAM1 JCAM UNQ264/PRO301 JAM, KAT, JAM1, JAMA, JCAM, CD321, JAM-1, JAM-A, PAM-1

Q9Y624

Human

WB,IF,ICC

WB 1:4000
IF 1:100
ICC 1:100-1:400

29.8 kDa

Mouse

Full length human recombinant protein of human F11R(NP_653087) produced in HEK293T cell.

Monoclonal

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Store at -20 °C. Stable for 12 months from date of receipt.