Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.; (Microbial infection) Acts as an attachment receptor for Ebolavirus.; (Microbial infection) Acts as an attachment receptor for Hepatitis C virus.; (Microbial infection) Acts as an attachment receptor for HIV-1.; (Microbial infection) Acts as an attachment receptor for Human coronavirus 229E.; (Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5.; (Microbial infection) Acts as an attachment receptor for Influenzavirus.; (Microbial infection) Acts as an attachment receptor for SARS-CoV.; (Microbial infection) Acts as an attachment receptor for West-nile virus.; (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.; (Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein.; (Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule.

C-type lectin domain family 4 member M (CD209 antigen-like protein 1) (DC-SIGN-related protein) (DC-SIGNR) (Dendritic cell-specific ICAM-3-grabbing non-integrin 2) (DC-SIGN2) (Liver/lymph node-specific ICAM-3-grabbing non-integrin) (L-SIGN) (CD antigen CD299)
CLEC4M CD209L CD209L1 CD299 CD209L; CD299; DC-SIGN2; DC-SIGNR; DCSIGNR; HP10347; L-SIGN; LSIGN

Q9H2X3

Human

IHC

IHC 1:150

45.2 kDa

Mouse

Human recombinant protein fragment corresponding to amino acids 74-329 of human CLEC4M (NP_055072) produced in E.coli.

Monoclonal

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Store at -20 °C. Stable for 12 months from date of receipt.