3''-5'' RNA exonuclease that trims the 3'' end of oligo(U) and oligo(A) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3'' end-terminated with a 2'',3''-cyclic phosphate (PubMed:22899009, PubMed:23022480, PubMed:23190533, PubMed:26213367, PubMed:28887445, PubMed:30215753, PubMed:31832688). Participates in the U6 snRNA 3'' end processing that prevents U6 snRNA degradation (PubMed:22899009, PubMed:23022480, PubMed:23190533, PubMed:26213367, PubMed:28887445, PubMed:30215753, PubMed:31832688). In addition also removes uridines from the 3'' end of U6atac snRNA and possibly the vault RNA VTRNA1-1 (PubMed:26213367).

U6 snRNA phosphodiesterase 1 (hUsb1) (3''-5'' RNA exonuclease USB1) (EC 4.6.1.-) (Mutated in poikiloderma with neutropenia protein 1) (Mutated in PN protein 1) (hMpn1)
USB1 C16orf57 Mpn1 C16orf57; hUsb1; HVSL1; Mpn1; PN

Q9BQ65

Human

WB

WB 1:500-2000

30.1 kDa

Mouse

Full length human recombinant protein of human C16orf57 (NP_078874) produced in E.coli.

Monoclonal

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Store at -20 °C. Stable for 12 months from date of receipt.