HGF is a pleiotropic protein in the plasminogen subfamily of S1 peptidases. HGF is a potent, mesenchymally-derived mitogen for mature parenchymal hepatocytes, and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Human HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide. HGF regulates many physiological processes including proliferation, scattering, morphogenesis and survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries.

This recombinant human HGF is produced by human cells. (Tag free)

Biological activity:

The activity was measured by its ability to stimulate the proliferation of the monkey epithelial cell line 4MBr-5.

Reconstitution:

Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

HGF alpha; HGFA; F TCF; Hepatocyte growth factor; Fibroblast derived tumor cytotoxic factor; Hepatocyte growth factor precursor; Hepatopoietin A; HPTA; Lung fibroblast derived mitogen; Scatter factor; SF; hepatocyte growth factor alpha-chain; Hepatocyte growth factor alpha chain; HGF_HUMAN.

Liquid

AC

22.9 kDa

20mM Tris-Hcl (pH=8.0) with 8M Urea and 2mM DTT

Cancer > Invasion/microenvironment > Angiogenesis > Angiogenic growth factors

Signal Transduction > Growth Factors/Hormones > Hormones

Dimer of an alpha chain and a beta chain linked by a disulfide bond.

Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39) [MIM:608265]. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Belongs to the peptidase S1 family. Plasminogen subfamily.

Contains 4 kringle domains.

Contains 1 PAN domain.

Contains 1 peptidase S1 domain.

P14210

3082

32-208/728

Human

N-His

>90% as determined by SDS-PAGE

Not analyzed

E.coli

9.56

Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. It has no detectable protease activity.

Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Entrez Gene : 3082 Human

Entrez Gene : 282879 Cow

Entrez Gene : 15234 Mouse

Entrez Gene : 24446 Rat

Omim : 142409 Human

SwissProt : Q9BH09 Cat

SwissProt : Q76BS1 Cow

SwissProt : Q867B7 D