Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the ''Lys-48''-linked polyubiquitination and degradation of TRAF6 in cortical neurons.

NUMBL;CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR; TNRC23

q9y6r0

Human,Mouse,Rat

WB

WB 1:2000

Monoclonal

64.7 kDa

Mouse

Human recombinant protein fragment corresponding to amino acids 1-225 of human NUMBL (NP_004747) produced in E.coli.

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.