Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA . This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12 . The resulting increased transcriptional activity drives cell proliferation . Binds to 5''-TGTCG[CT]GA[CT]A-3'' consensus sequences in gene promoters of ribosomal proteins .; (Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection.

DREF;ALTE; DREF; hDREF; TRAMP

o96006

Human

WB,IHC,FC

WB 1:2000
IHC 1:150
FC 1:100

Monoclonal

78 kDa

Mouse

Full length human recombinant protein of human ZBED1(NP_004720) produced in HEK293T cell.

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.