Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

P25963

I kappa B alpha; I-kappa-B-alpha; IkappaBalpha; IkB-alpha; IKBA; IKBA_HUMAN; IKBalpha; MAD 3; MAD3; Major histocompatibility complex enhancer-binding protein MAD3; NF kappa B inhibitor alpha; NF-kappa-B inhibitor alpha; NFKBI; NFKBIA; Nuclear factor of kappa light chain gene enhancer in B cells; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha;

IKB alpha Antibody detects endogenous levels of total IKB alpha.

Human,,Mouse,,Rat,,Cow,,Pig,,Sheep,,Chicken,,Cat,,Dog,

Mouse

WB 1:1000-1:2000
IHC 1:50-1:200
IF 1:100-1:400
ICC 1:100-1:400

40kD; 36kDa(Calculated).

Store at -20 °C. Stable for 12 months from date of receipt.

WB 1:1000-1:2000; IF/IHC 1:100-1:500

Western blot analysis of IKB alpha using Lane1: THP-1 cell lysates and Lane2: mouse spleen lysates.