Choline uniporter that specifically mediates choline uptake at the blood-brain-barrier . Responsible for the majority of choline uptake across the blood-brain-barrier from the circulation into the brain (By similarity). Choline, a nutrient critical for brain development, is a precursor of phosphatidylcholine, as well as betaine (By similarity). Also mediates transport of ethanolamine . Choline and ethanolamine transport is not coupled with proton transport and is exclusively driven by the choline gradient across the plasma membrane . However, the presence of an inwardly directed proton gradient enhances choline uptake (By similarity). Also acts as a heme b transporter . Required to regulate mitochondrial respiration processes, ATP synthesis and thermogenesis . At low heme levels, interacts with components of electron transfer chain (ETC) complexes and ATP2A2, leading to ubiquitin-mediated degradation of ATP2A2 and inhibition of thermogenesis . Upon heme binding, dissociates from ETC complexes to allow switching from mitochondrial ATP synthesis to thermogenesis . .

Choline/ethanolamine transporter FLVCR2 (Calcium-chelate transporter) (CCT) (Feline leukemia virus subgroup C receptor-related protein 2) (Heme transporter FLVCR2),FLVCR2 C14orf58

Q9UPI3,Q91X85,P60815

55640/217721

Human,Mouse,Rat

WB

WB 1:500-2000

This antibody detects endogenous levels of FLVC2 at Human/Mouse/Rat

58kDa

Rabbit

Synthesized peptide derived from human FLVC2 AA range: 352-402

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.