Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay . Essential for both oocyte maturation and fertility. Through 3'' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets . Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms . Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A . In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3'' end overhang for efficient processing . Add oligo-U tails to truncated pre-miRNAS with a 5'' overhang which may promote rapid degradation of non-functional pre-miRNA species . Does not play a role in replication-dependent histone mRNA degradation . Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult . TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules . .

Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 6),TUT7 HS2 KIAA1711 ZCCHC6

Q5VYS8,Q5BLK4

79670/214290

Human,Mouse

WB

WB 1:500-2000

This antibody detects endogenous levels of TUT7 at Human/Mouse

164kDa

Rabbit

Synthesized peptide derived from human TUT7.

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.