Acetylates histones, giving a specific tag for transcriptional activation . Mediates acetylation of histone H3 at ''Lys-18'' and ''Lys-27'' (H3K18ac and H3K27ac, respectively) . Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 . Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers . Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) . Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region . Acetylates DDX21, thereby inhibiting DDX21 helicase activity . Acetylates FBL, preventing methylation of ''Gln-105'' of histone H2A (H2AQ104me) . In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation . Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) . Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway . .

CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-),CREBBP CBP

Q92793,P45481,Q6JHU9

1387

Human,Mouse,Rat

WB,IHC,IF,ICC,ELISA

WB 1:500-1:2000
IHC 1:100-1:300
IF 1:50-200
ICC 1:50-200
ELISA 1:20000

Acetyl-CBP (K1535) Polyclonal Antibody detects endogenous levels of CBP protein only when acetylated at K1535.

265kDa

Rabbit

Synthesized peptide derived from human CBP around the acetylated site of Lys1535.

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.