E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway . Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing ''Lys-29''-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1 . Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating ''Lys-63''-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex . Also involved in protein trafficking and localization . Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2 . Does not catalyze ubiquitination of GluA1/GRIA1 . Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3 . Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B . Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18 . Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N . .

E3 ubiquitin-protein ligase RNF167 (EC 2.3.2.27) (RING finger protein 167),RNF167 RING105 LP2254

Q9H6Y7,Q91XF4,Q5XIL0

26001

Human,Mouse,Rat

WB,ELISA

WB 1:500-2000
ELISA 1:5000-20000

RN167 Polyclonal Antibody detects endogenous levels of protein.

38kDa

Rabbit

Synthesized peptide derived from part region of human protein

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.