Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades . The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state . Signaling by an activated GPCR promotes GDP release and GTP binding . The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal . Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins . Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNA11 activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) . Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) . Together with GNAQ, required for heart development (By similarity). In the respiratory epithelium, transmits OXGR1-dependent signals that lead to downstream intracellular Ca(2+) release and mucocilliary clearance of airborne pathogens. .

Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (EC 3.6.5.-) (Guanine nucleotide-binding protein G(y) subunit alpha),GNA11 GA11

P29992,P21278,Q9JID2

2767

Human,Rat,Mouse

WB,ELISA

WB 1:500-2000
ELISA 1:5000-20000

GNA11 Polyclonal Antibody detects endogenous levels of protein.

39kDa

Rabbit

Synthesized peptide derived from part region of human protein

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.