[Isoform 1]: Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts . Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes . Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner . Promotes biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane . In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts . Does not confer multidrug resistance (By similarity). .

Phosphatidylcholine translocator ABCB4 (EC 7.6.2.1) (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 3) (P-glycoprotein 3),ABCB4 MDR3 PGY3

P21439,P21440,Q08201

5244

Human,Rat,Mouse

WB,ELISA

WB 1:500-2000
ELISA 1:5000-20000

MDR3 Polyclonal Antibody detects endogenous levels of protein.

141kDa

Rabbit

Synthesized peptide derived from human protein . at AA range: 20-100

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.