Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination . Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51 . Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation . Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair . WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2 . Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination . Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination . May also bind RNA; additional evidences are however required to confirm RNA-binding in vivo . .

RAD51-associated protein 1 (HsRAD51AP1) (RAD51-interacting protein),RAD51AP1 PIR51

Q96B01,Q8C551

10635

Human,Mouse

WB,ELISA

WB 1:500-2000
ELISA 1:5000-20000

R51A1 Polyclonal Antibody detects endogenous levels of protein.

38kDa

Rabbit

Synthesized peptide derived from human protein.

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.