Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation . Connects chromatin mediated regulation of transcription and pre-mRNA splicing . During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) . Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation . Associates and probably phosphorylates SMARCA4 and NCOR1 . Phosphorylates SRSF1 . Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores . Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 . Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control . .

Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog),PRP4K KIAA0536 PRP4 PRP4B PRP4H PRPF4K

Q13523,Q61136,Q5RKH1

8899

Human,Rat,Mouse

WB,ELISA

WB 1:500-2000
ELISA 1:5000-20000

PRP4B Polyclonal Antibody detects endogenous levels of protein.

110kDa

Rabbit

Synthesized peptide derived from part region of human protein

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.