Exhibits weak E3 ubiquitin-protein ligase activity . E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates . Can ubiquitinate AKT1 preferentially at ''Lys-284'' involving ''Lys-48''-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteasomal degradation . Mediates polyubiquitination of cytoplasmic TP53 at ''Lys-24'' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion . Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations . Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization . Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway . May also be involved in the sumoylation of the membrane fission protein DNM1L . Inhibits cell growth . When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis . Involved in the modulation of innate immune defense against viruses by inhibiting RIGI-dependent antiviral response . Can mediate RIGI sumoylation and disrupt its polyubiquitination . .

Mitochondrial ubiquitin ligase activator of NFKB 1 (EC 2.3.2.27) (E3 SUMO-protein ligase MUL1) (E3 ubiquitin-protein ligase MUL1) (Growth inhibition and death E3 ligase) (Mitochondrial-anchored protein ligase) (Protein Hades) (Putative NF-kappa-B-activating protein 266) (RING finger protein 218) (RING-type E3 ubiquitin transferase NFKB 1),MUL1 C1orf166 GIDE MAPL MULAN RNF218

Q969V5,Q8VCM5

79594

Human,Mouse

WB,ELISA

WB 1:500-2000
ELISA 1:5000-20000

MUL1 Polyclonal Antibody detects endogenous levels of protein.

38kDa

Rabbit

Synthesized peptide derived from part region of human protein

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.