E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins . Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 . Mediates monoubiquitination of DNA polymerase beta (POLB) at ''Lys-41'', ''Lys-61'' and ''Lys-81'', thereby playing a role in base-excision repair . Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 . Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC . Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination . Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN . May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation . Mediates polyubiquitination of isoform 2 of PA2G4 . Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 . Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling . Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic ''Lys-63''-/''Lys-48''-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of ''Lys-48''-linked chains of substrates initially modified with ''Lys-63''-linked conjugates by TRAF6 . ''Lys-63''-/''Lys-48''-linked branched ubiquitin chains protect ''Lys-63''-linkages from CYLD deubiquitination . Ubiquitinates PPARA in hepatocytes (By similarity). .

E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1),HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272

Q7Z6Z7,Q7TMY8

10075

Human,Mouse

IHC,IF,ICC

IHC 1:50-300
IF 1:50-200
ICC 1:50-200

HUWE1 Polyclonal Antibody detects endogenous levels of protein.

Rabbit

Synthesized peptide derived from part region of human protein

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.