Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi . The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6''-dimycolate (TDM) . Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes . The heterodimer formed with CLEC6A is active against fungal infection . Functions as an endocytic receptor . May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells . .

C-type lectin domain family 4 member D (C-type lectin superfamily member 8) (C-type lectin-like receptor 6) (CLEC-6) (Dendritic cell-associated C-type lectin 3) (DC-associated C-type lectin 3) (Dectin-3) (CD antigen CD368),CLEC4D CLECSF8 MCL

Q8WXI8,Q9Z2H6,Q69FH1

338339

Human,Rat,Mouse

WB,ELISA

WB 1:500-2000
ELISA 1:5000-20000

CLC4D Polyclonal Antibody detects endogenous levels of protein.

23kDa

Rabbit

Synthesized peptide derived from part region of human protein

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.