Adhesion G-protein coupled receptor (aGPCR) for glucocorticoid hormones such as cortisol, cortisone and 11-deoxycortisol . Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase . ADGRG3/GPR97 is coupled to G(o)/GNAO1 G proteins and mediates signaling by inhibiting adenylate cyclase activity . May also signal through G-alpha(q)-proteins; additional evidence are however required to confirm this result in vivo . Plays a role in the regulation of various processes including B-cell development, inflammation or innate immunity . Regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 . Antibody ligation leads to the production and activation of antimicrobial mediators like reactive oxygen species (ROS) and myeloperoxidase (MPO) as well as enhanced bacteria uptake and killing by granulocytes . Additionally, collaborates with protease-activated receptor 2/PAR2 to stimulate neutrophil-driven antimicrobial responses and endothelial cell activation . .

Adhesion G protein-coupled receptor G3 (G-protein coupled receptor 97) [Cleaved into: Adhesion G-protein coupled receptor G3, N-terminal fragment (ADGRG3 N-terminal fragment); Adhesion G-protein coupled receptor G3, C-terminal fragment (ADGRG3 C-terminal fragment)],ADGRG3 GPR97 PGR26

Q86Y34,Q8R0T6

222487

Human,Rat,Mouse

WB,ELISA

WB 1:500-2000
ELISA 1:5000-20000

GPR97 Polyclonal Antibody detects endogenous levels of protein.

60kDa

Rabbit

Synthesized peptide derived from human protein . at AA range: 210-290

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.