Contributes to the organization of the actin cytoskeleton and cell shape . Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement . Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane . Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane . Plays a role in the invasiveness of cancer cells, and the formation of metastases . .

Src substrate cortactin (Amplaxin) (Oncogene EMS1),CTTN EMS1

Q14247,Q60598

2017/13043

Human,Mouse,Rat

WB,IHC,IF,ICC,ELISA

WB 1:500-1:2000
IHC 1:100-1:300
IF 1:50-200
ICC 1:50-200
ELISA 1:20000

Phospho-Cortactin (Y421) Polyclonal Antibody detects endogenous levels of Cortactin protein only when phosphorylated at Y421.

80kDa

Rabbit

Synthesized peptide derived from human Cortactin around the phosphorylation site of Tyr421.

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.