Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis . Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis . Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules . Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at ''Thr-3'' (H3pT3) during mitosis . The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules . May counteract a default induction of apoptosis in G2/M phase . The acetylated form represses STAT3 transactivation of target gene promoters . May play a role in neoplasia . Inhibitor of CASP3 and CASP7 . Essential for the maintenance of mitochondrial integrity and function . Isoform 2 and isoform 3 do not appear to play vital roles in mitosis . Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform . .

Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin),BIRC5 API4 IAP4

O15392,O70201,Q9JHY7

332/11799/64041

Human,Mouse,Rat

WB,IHC,ELISA

WB 1:500-2000
IHC 1:50-300
ELISA 2000-20000

Phospho-Survivin (T34) Polyclonal Antibody detects endogenous levels of Survivin protein only when phosphorylated at T34.

16kDa

Rabbit

Synthesized peptide derived from human Survivin around the phosphorylation site of Thr34.

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.