Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor . Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways . Can recognize and bind both ''Lys-63''-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin . Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 . Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires ''Lys-27''-linked polyubiquitination . .; (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B. .

NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier),IKBKG FIP3 NEMO

Q9Y6K9,O88522

8517

Human,Rat,Mouse

WB,IHC,IF,ICC,ELISA

WB 1:500-2000
IHC 1:50-300
IF 1:50-200
ICC 1:50-200
ELISA 1:40000

Phospho-IKKγ (S85) Polyclonal Antibody detects endogenous levels of IKKγ protein only when phosphorylated at S85.

48kDa

Rabbit

Synthesized peptide derived from human IKK-gamma around the phosphorylation site of Ser85.

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.