Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5''-CANNTG-3'' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer . Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). .; [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5''-CAGGTG-3'', and positively regulates transcriptional activity. .

Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1),TCF3 BHLHB21 E2A ITF1

P15923,P15806,P21677

6929/21423/171046

Human,Mouse,Rat

IHC,IF,ICC,ELISA

IHC 1:50-300
IF 1:50-200
ICC 1:50-200
ELISA 1:5000

Phospho-E2A (T355) Polyclonal Antibody detects endogenous levels of E2A protein only when phosphorylated at T355.

Rabbit

Synthesized peptide derived from human E2A around the phosphorylation site of Thr355.

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.