A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling . Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 . Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs . Acts as a 1,4-cineole 2-exo-monooxygenase . .; Allele 2B6*9: Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs. .

Cytochrome P450 2B6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIB6) (Cytochrome P450 IIB1),CYP2B6

P20813

1555

Human

WB,IHC,IF,ICC,ELISA

WB 1:500-2000
IHC 1:50-300
IF 1:50-200
ICC 1:50-200
ELISA 1:5000

CYP2B6 Polyclonal Antibody detects endogenous levels of CYP2B6 protein.

56kDa

Rabbit

The antiserum was produced against synthesized peptide derived from human Cytochrome P450 2B6. AA range:241-290

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.