G-protein coupled receptor that binds to several ligands including the tryptophan metabolite kynurenic acid (KYNA), lysophosphatidic acid (LPA) or 5-hydroxyindoleacetic acid (5-HIAA) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways . Plays a role in neutrophil recruitment to sites of inflammation and bacterial clearance through the major serotonin metabolite 5-HIAA that acts as a physiological ligand . Stimulates lipid metabolism, thermogenic, and anti-inflammatory gene expression in adipose tissue once activated by kynurenic acid (By similarity). In macrophages, activation by lysophosphatidic acid promotes GPR35-induced signaling with a distinct transcriptional profile characterized by TNF production associated with ERK and NF-kappa-B activation. In turn, induces chemotaxis of macrophages (By similarity). .

G-protein coupled receptor 35 (Kynurenic acid receptor) (KYNA receptor),GPR35

Q9HC97,Q9ES90

2859

Human,Rat,Mouse

WB,IHC,IF,ICC,ELISA

WB 1:500-2000
IHC 1:200-1:1000
IF 1:50-200
ICC 1:50-200
ELISA 1:20000

GPR35 Polyclonal Antibody detects endogenous levels of GPR35 protein.

34kDa

Rabbit

The antiserum was produced against synthesized peptide derived from human GPR35. AA range:51-100

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.