Serine/threonine-protein kinase . Phosphorylates the microtubule-associated protein MAPT/TAU . Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 . Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles . Required for the initiation of axoneme extension during cilium assembly . Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro . Plays a role in cell cycle progression, specifically in the G1/S checkpoint . Reduces neuronal cell survival . Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation . Involved in NLRP3 positioning along microtubules by mediating NLRP3 recruitment to microtubule organizing center (MTOC) upon inflammasome activation . .

MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1),MARK4 KIAA1860 MARKL1

Q96L34,Q8CIP4

57787/232944

Human,Mouse

IHC,IF,ICC,ELISA

IHC 1:200-1:1000
IF 1:50-200
ICC 1:50-200
ELISA 1:40000

MARK4 Polyclonal Antibody detects endogenous levels of MARK4 protein.

Rabbit

The antiserum was produced against synthesized peptide derived from human MARK4. AA range:461-510

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.