Forms pH-gated heterotrimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system . Upon extracellular acidification, these channels generate a biphasic current with a fast inactivating and a slow sustained phase . ASIC3 is more sensitive to protons and gates between closed, open, and desensitized states faster than other ASICs (By similarity). Displays high selectivity for sodium ions but can also permit the permeation of other cations . As a neuronal acid sensor, probably contributes to mechanoreception, acid nociception, and heat nociception (By similarity). By forming heterotrimeric channels with ASIC2, generates a biphasic current with a fast inactivating and a slow sustained phase, which in sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissues (By similarity). .

Acid-sensing ion channel 3 (ASIC3) (hASIC3) (Amiloride-sensitive cation channel 3) (Neuronal amiloride-sensitive cation channel 3) (Testis sodium channel 1) (hTNaC1),ASIC3 ACCN3 DRASIC SLNAC1 TNAC1

Q9UHC3,Q6X1Y6

9311

Human,Rat,Mouse

WB,ELISA

WB 1:500-2000
ELISA 1:20000

ASIC3 Polyclonal Antibody detects endogenous levels of ASIC3 protein.

58kDa

Rabbit

The antiserum was produced against synthesized peptide derived from the Internal region of human ASIC3. AA range:191-240

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.