Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory . Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents . Displays high selectivity for sodium ions but can also permit the permeation of other cations . Regulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines. Modulates neuronal activity in the circuits underlying innate fear (By similarity). .; [Isoform Asic1a]: Has high selectivity for sodium ions, but can also be permeable to other cations including calcium, lithium and potassium. .; [Isoform Asic1b]: Produces acid activated currents with a reduced amplitude and inactivates faster . Has high selectivity for sodium ions but also supports a calcium-mediated current which is sustained and maintained as long as acidic conditions are present . Also potentially permeable to lithium and potassium . .; [Isoform 1]: Has no measurable proton-gated sodium channel activity in vitro. .

Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2),ASIC1 ACCN2 BNAC2

P78348,Q6NXK8,P55926

41/11419

Human,Mouse,Rat

WB,IHC,IF,ICC,ELISA

WB 1:500-2000
IHC 1:50-300
IF 1:50-200
ICC 1:50-200
ELISA 1:10000-20000

The antibody detects endogenous ASIC1

70-75kDa

Rabbit

Synthetic peptide from human protein at AA range: 220-280

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.