Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis . The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ . Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration . Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint . Negatively regulates G2/M transition by down-regulating CDK1 kinase activity . Involved in the control of p53 expression . Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 . May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 . Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of ''Ser-265'' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 . .

Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts),LATS1 WARTS

O95835,Q8BYR2

9113/16798

Human,Mouse,Rat

WB,IHC,ELISA

WB 1:500-2000
IHC 1:50-300
ELISA 2000-20000

This antibody detects endogenous levels of LATS1/2 antibody

140kDa

Rabbit

Synthesized peptide derived from human LATS1/2 AA range: 1050-1130

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.