Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L-thyroxine sulfate (T4S), and 3,3'',5''-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane . Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases . Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases . Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency . Transports T4 and E1S in a pH-insensitive manner . Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain . .

Solute carrier organic anion transporter family member 1C1 (Organic anion transporter 1C1) (OATP1C1) (Organic anion transporter F) (OATP-F) (Organic anion transporter polypeptide-related protein 5) (OAT-RP-5) (OATP-RP5) (Organic anion-transporting polypeptide 14) (OATP-14) (Solute carrier family 21 member 14) (Thyroxine transporter),SLCO1C1 OATP14 OATP1C1 OATPF SLC21A14

Q9NYB5,Q9ERB5,Q9EPZ7

53919/58807/84511

Human,Mouse,Rat

WB,IHC,ELISA

WB 1:500-2000
IHC 1:50-300
ELISA 2000-20000

This antibody detects endogenous levels of SO1C1 at Human/Mouse/Rat

78kDa

Rabbit

Synthesized peptide derived from human SO1C1 AA range: 634-684

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.