RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5''-splice site (5''-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5''-ss usage through the 5''-CGGGCA-3'' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5'' ss in a 5''-CGGGCA-3''-dependent manner. Binds to the exonic splicing enhancer 5''-CGGGCA-3'' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. .

RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7),RBM25 RNPC7

P49756,B2RY56

58517/67039

Human,Mouse

WB,IHC

WB 1:500-2000
IHC 1:50-300

This antibody detects endogenous levels of RBM25 at Human/Mouse

93kDa

Rabbit

Synthesized peptide derived from human RBM25.

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.