DNA helicase that plays an important role in DNA replication, transcription and repair . Probably unwinds DNA in a 3''-5'' direction (Probable) . Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability . Also associates with POLR1A and enforces the stability of ribosomal DNA arrays . Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress . Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis . Required for efficient DNA repair, including repair of inter-strand cross-links . Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. A core helicase fragment (residues 11-609) binds preferentially to splayed duplex, looped and ssDNA . .

ATP-dependent DNA helicase Q5 (EC 5.6.2.4) (DNA 3''-5'' helicase RecQ5) (DNA helicase, RecQ-like type 5) (RecQ5) (RecQ protein-like 5),RECQL5 RECQ5

O94762

9400

Human,Rat,Mouse

WB,IHC,ELISA

WB 1:500-2000
IHC 1:50-300
ELISA 2000-20000

This antibody detects endogenous levels of RECQ5 at Human

109kDa

Rabbit

Synthesized peptide derived from human RECQ5.

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.