Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for ''once per cell cycle'' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built . The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity . Required for the entry in S phase and for cell division . Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis . .

DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28),MCM2 BM28 CCNL1 CDCL1 KIAA0030

P49736,P97310

4171/17216

Human,Mouse,Rat

WB,IHC

WB 1:500-2000
IHC 1:50-300

This antibody detects endogenous levels of Human Mouse Rat MCM2 (phospho-Ser139)

120kDa

Rabbit

Synthesized phosho peptide around human MCM2 (Ser139)

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.