Component of the BRCA1-A complex, a complex that specifically recognizes ''Lys-63''-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ''Lys-63''-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves ''Lys-63''-linked ubiquitin in various substrates . In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the ''Lys-63''-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 . Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression . Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination . .

BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex),BABAM1 C19orf62 MERIT40 NBA1 HSPC142

Q9NWV8,Q3UI43,Q5XIJ6

29086/68251/290631

Human,Rat,Mouse

WB,IHC

WB 1:500-2000
IHC 1:50-300

This antibody detects endogenous levels of Human MERIT40 (phospho-Ser29)

36kDa

Rabbit

Synthesized phosho peptide around human MERIT40 (Ser29)

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.