Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of ''Lys-63''-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) . Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to ''Lys-63''-linked polyubiquitin chains . The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63''-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 . Also recognizes and binds Lys-63''-linked polyubiquitin chains of heterotypic ''Lys-63''-/''Lys-48''-linked branched ubiquitin chains . Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development . .

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2),TAB2 KIAA0733 MAP3K7IP2

Q9NYJ8,Q99K90,Q5U303

23118/68652/308267

Human,Mouse,Rat

WB

WB 1:500-2000

This antibody detects endogenous levels of Human Mouse Rat TAB2 (phospho-Ser372)

77kDa

Rabbit

Synthesized phosho peptide around human TAB2 (Ser372)

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.