Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis . Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome . The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation . Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 . Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). .; (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. .

Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7),EEF1A1 EEF1A EF1A LENG7

P68104/Q05639/Q5VTE0,P10126,P62630

1915/13627/171361

Human,Mouse,Rat

WB,ELISA

WB 1:500-2000
ELISA 1:5000-20000

This antibody detects endogenous levels of Human,Mouse,Rat EF-1 α1/2 (Acetyl Lys146)

51kDa

Rabbit

Synthesized peptide derived from human EF-1 α1/2 (Acetyl Lys146)

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.