Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site . Binds to the consensus sequence 5''-CCGCCATNTT-3''; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity . The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes . Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression . For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence . Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression . Binds to SMAD binding elements (SBEs) (5''-GTCT/AGAC-3'') within BMP response element (BMPRE) of cardiac activating regions . May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed . Involved in DNA repair . In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation . Recruits the PR-DUB complex to specific gene-regulatory regions . .; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. .

Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1),YY1 INO80S

P25490,Q00899

7528/22632

Human,Mouse

WB,ELISA

WB 1:500-2000
ELISA 1:5000-20000

This antibody detects endogenous levels of Human,Mouse YY1 (Acetyl Lys351)

55kDa

Rabbit

Synthesized peptide derived from human YY1 (Acetyl Lys351)

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.